| ITF W60 - Prag | 05/03 08:30 | 25 | [268] Maja Chwalinska v Despina Papamichail [172] | 7-6,6-1 | |
| ITF W60 - Zagreb | 04/27 13:35 | 26 | [172] Despina Papamichail v Petra Marcinko [388] | 1-6,3-6 | |
| ITF W60 - Zagreb | 04/26 07:50 | 25 | [172] Despina Papamichail v Jana Fett [236] | Retired | |
| WTA Istanbul | 04/18 16:30 | 19 | [96] Qiang Wang v Despina Papamichail [173] | 6-1,6-1 | |
| WTA Istanbul | 04/17 09:15 | 14 | [200] Ysaline Bonaventure v Despina Papamichail [172] | 4-6,6-7 | |
| Billie Jean King Cup | 04/15 13:15 | 2 | [172] Despina Papamichail v Mandy Minella [251] | 1-6,0-6 | |
| Billie Jean King Cup | 04/14 14:10 | 2 | [172] Despina Papamichail v Maiar S A Abdelaziz [62] | 3-6,3-6 | |
| Billie Jean King Cup | 04/13 13:25 | 2 | [172] Despina Papamichail v Ulrikke Eikeri [239] | 2-6,7-5,6-4 | |
| WTA Bogota | 04/04 15:00 | 25 | [172] Despina Papamichail v Lucrezia Stefanini [159] | 3-6,4-6 | |
| ITF W25 - Le Havre | 03/24 10:00 | 26 | [253] Irene Burillo Escorihuela v Despina Papamichail [171] | 7-5,3-6,7-6 | |
| ITF W25 - Le Havre | 03/22 11:15 | 25 | Astrid Lew Yan Foon v Despina Papamichail | 0-6,0-6 | |
| ITF W25 - Antalya | 03/16 07:00 | 25 | Nicole Khirin v Despina Papamichail | 7-6,6-1 | |
| WTA Lyon | 02/26 15:00 | 14 | [176] Despina Papamichail v Mariam Bolkvadze [161] | 6-3,4-6,1-6 | |
| WTA Guadalajara | 02/19 20:30 | 14 | Viktoria Kuzmova v Despina Papamichail | 6-4,6-3 | |
| ITF W25 - Cancún | 02/09 18:00 | 25 | Despina Papamichail v Stacey Fung | 2-6,4-6 | |
| ITF W60 - Rome, GA | 02/03 15:50 | 26 | [175] Despina Papamichail v Francesca Di Lorenzo [203] | 1-6,3-6 | |
| ITF W60 - Rome, GA | 02/01 18:25 | 25 | [175] Despina Papamichail v Jodie Anna Burrage [209] | 6-7,7-6,6-0 | |
| ITF W60 - Orlando | 01/27 16:25 | 25 | [181] Despina Papamichail v Qinwen Zheng [108] | 4-6,2-6 | |
| Australian Open - Damer | 01/10 23:00 | 14 | [119] Viktoriya Tomova v Despina Papamichail [183] | 6-2,4-6,6-1 | |
| WTA Adelaide | 01/04 06:20 | 25 | [182] Despina Papamichail v Marie Bouzkova [90] | 3-6,0-6 | |
| WTA Adelaide | 01/03 07:05 | 19 | [147] Stefanie Voegele v Despina Papamichail [182] | 4-6,6-7 | |
| WTA Adelaide | 01/02 07:50 | 14 | [182] Despina Papamichail v Francesca Jones [151] | 3-6,6-2,6-1 | |
| WTA Buenos Aires | 11/05 13:00 | 27 | [135] Anna Bondar v Despina Papamichail [199] | 6-4,7-5 | |
| WTA Buenos Aires | 11/04 13:00 | 26 | Solana Sierra v Despina Papamichail | 6-7,4-6 | |
| WTA Buenos Aires | 11/02 18:00 | 25 | [261] Maria Lourdes Carle v Despina Papamichail [199] | 6-3,2-6,2-6 | |
| ITF W25 - Seville | 10/19 12:40 | 25 | Yvonne Cavalle-Reimers v Despina Papamichail | 6-2,6-4 | |
| ITF W25 - Lagos | 10/16 10:35 | 28 | Despina Papamichail v Antonia Ruzic | 1-6,1-6 | |
| ITF W25 - Lagos | 10/15 12:00 | 27 | [210] Despina Papamichail v Naiktha Bains [264] | 6-1,6-1 | |
| ITF W25 - Lagos | 10/14 12:00 | 26 | [210] Despina Papamichail v Miriam B Bulgaru [404] | 3-6,6-3,7-6 | |
| ITF W25 - Lagos | 10/13 12:55 | 25 | Despina Papamichail v Ines Murta | 6-3,6-4 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.