Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Jimmy Rogers
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | L | 42-41 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | W | 26-31 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | W | 44-3 |
| NCAAF | 2019/10/05 19:00 | SO Illinois v South Dakota State | W | 10-28 |
| NCAAF FCS | 2018/11/10 19:00 | South Dakota State v SO Illinois | W | 57-38 |
| NCAAF | 2017/10/07 23:00 | South Dakota State v SO Illinois | W | 49-14 |