[3] Club Brügge 0-5 RB Leipzig [4] 2021-11-24 20:00
Stadium: Jan Breydel Stadium Round: 5
Referee: Davide Massa Home Manager: Philippe Clement Away Manager: Jesse Marsch
Head to Head
| UEFA Champions League | 2021/09/28 19:00 | RB Leipzig v Club Brügge | W | 1-2 |
Home History
| Belgien - First Division A | 2021/11/19 19:45 | KV Mechelen v Club Brügge | L | 2-1 |
| Belgien - First Division A | 2021/11/07 12:30 | Club Brügge v Standard Liege | D | 2-2 |
| UEFA Champions League | 2021/11/03 20:00 | Man City v Club Brügge | L | 4-1 |
| Belgien - First Division A | 2021/10/30 18:45 | Sint-Truidense v Club Brügge | W | 1-2 |
| Belgien - Cup | 2021/10/27 18:45 | Club Brügge v Deinze | W | 3-0 |
| Belgien - First Division A | 2021/10/24 11:30 | Antwerpen v Club Brügge | D | 1-1 |
| UEFA Champions League | 2021/10/19 16:45 | Club Brügge v Man City | L | 1-5 |
| Belgien - First Division A | 2021/10/15 18:45 | Club Brügge v KV Kortrijk | W | 2-0 |
Away History
| Tyskland - Bundesliga I | 2021/11/20 14:30 | TSG Hoffenheim v RB Leipzig | L | 2-0 |
| Tyskland - Bundesliga I | 2021/11/06 17:30 | RB Leipzig v Borussia Dortmund | W | 2-1 |
| UEFA Champions League | 2021/11/03 20:00 | RB Leipzig v PSG | D | 2-2 |
| Tyskland - Bundesliga I | 2021/10/30 16:30 | Eintracht Frankfurt v RB Leipzig | D | 1-1 |
| Tyskland - DFB Pokal | 2021/10/26 16:30 | Babelsberg 03 v RB Leipzig | W | 0-1 |
| Tyskland - Bundesliga I | 2021/10/23 13:30 | RB Leipzig v Greuther Furth | W | 4-1 |
| UEFA Champions League | 2021/10/19 19:00 | PSG v RB Leipzig | L | 3-2 |
| Tyskland - Bundesliga I | 2021/10/16 13:30 | SC Freiburg v RB Leipzig | D | 1-1 |