[5] Stefanos Tsitsipas 5-7,6-3,7-6,6-1 John Isner [34] 2021-06-04 19:00
Stadium: Court Philippe Chatrier Round: 25 Ground: Clay
Head to Head
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Shanghai | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |
Home History
| Franska öppna | 2021/06/02 13:50 | Stefanos Tsitsipas v Pedro Martinez | 6-3,6-4,6-3 |
| Franska öppna | 2021/05/30 18:30 | Stefanos Tsitsipas v Jeremy Chardy | 7-6,6-3,6-1 |
| ATP Lyon | 2021/05/23 12:00 | Cameron Norrie v Stefanos Tsitsipas | 3-6,3-6 |
| ATP Lyon | 2021/05/22 12:00 | Lorenzo Musetti v Stefanos Tsitsipas | 6-4,3-6,0-6 |
| ATP Lyon | 2021/05/21 10:20 | Yoshihito Nishioka v Stefanos Tsitsipas | 3-6,4-6 |
| ATP Lyon | 2021/05/20 13:00 | Tommy Paul v Stefanos Tsitsipas | 1-6,4-6 |
| ATP Rom | 2021/05/14 12:25 | Novak Djokovic v Stefanos Tsitsipas | 4-6,7-5,7-5 |
| ATP Rom | 2021/05/13 10:00 | Matteo Berrettini v Stefanos Tsitsipas | 6-7,2-6 |
Away History
| Franska öppna | 2021/06/02 12:35 | Filip Krajinovic v John Isner | 6-7,1-6,6-7 |
| Franska öppna | 2021/05/31 09:00 | Sam Querrey v John Isner | 6-7,3-6,4-6 |
| ATP Madrid | 2021/05/07 11:00 | Dominic Thiem v John Isner | 3-6,6-3,6-4 |
| ATP Madrid | 2021/05/06 13:20 | John Isner v Andrey Rublev | 7-6,3-6,7-6 |
| ATP Madrid | 2021/05/05 16:00 | Roberto Bautista-Agut v John Isner | 4-6,7-6,6-7 |
| ATP Madrid | 2021/05/03 09:00 | John Isner v Miomir Kecmanovic | 6-4,7-6 |
| ATP Miami | 2021/03/30 15:00 | John Isner v Roberto Bautista-Agut | 3-6,6-4,6-7 |
| ATP Miami | 2021/03/28 15:00 | Felix Auger Aliassime v John Isner | 6-7,6-7 |