[28] John Isner 3-6,6-4,6-7 Roberto Bautista-Agut [12] 2021-03-30 15:00
Stadium: Grandstand Round: 26 Ground: Hardcourt outdoor
Home History
| ATP Miami | 2021/03/28 15:00 | Felix Auger Aliassime v John Isner | 6-7,6-7 |
| ATP Miami | 2021/03/27 01:05 | Mackenzie McDonald v John Isner | 6-2,3-6,5-7 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP Acapulco | 2021/03/16 01:20 | John Isner v Salvatore Caruso | 6-4,6-3 |
| ATP Delray Beach | 2021/01/11 23:00 | Sebastian Korda v John Isner | 6-3,4-6,6-3 |
| ATP Delray Beach | 2021/01/10 01:35 | Thiago Monteiro v John Isner | 4-6,6-7 |
| Franska öppna | 2020/09/30 09:30 | Sebastian Korda v John Isner | 6-4,6-4,2-6,6-4 |
| Franska öppna | 2020/09/27 11:30 | Elliot Benchetrit v John Isner | 4-6,1-6,3-6 |
Away History
| ATP Miami | 2021/03/28 15:00 | Jan-Lennard Struff v Roberto Bautista-Agut | 6-4,3-6,2-6 |
| ATP Dubai | 2021/03/17 12:00 | Jannik Sinner v Roberto Bautista-Agut | 6-4,3-6,7-5 |
| ATP Doha | 2021/03/13 15:00 | Roberto Bautista-Agut v Nikoloz Basilashvili | 6-7,2-6 |
| ATP Doha | 2021/03/12 15:00 | Roberto Bautista-Agut v Andrey Rublev | 6-3,6-3 |
| ATP Doha | 2021/03/11 17:45 | Dominic Thiem v Roberto Bautista-Agut | 6-7,6-2,4-6 |
| ATP Doha | 2021/03/10 13:00 | Alexander Bublik v Roberto Bautista-Agut | 4-6,3-6 |
| ATP Doha | 2021/03/08 16:30 | Reilly Opelka v Roberto Bautista-Agut | 6-4,3-6,4-6 |
| ATP Rotterdam | 2021/03/03 15:00 | Alejandro Davidovich Fokina v Roberto Bautista-Agut | 6-2,7-6 |